反应详情

温度

90 °C

10 mg of 4-methanesulfonyl-phenol and 20 mg of cesium carbonate were added to a dimethylformamide (0.5 ml) solution of 21 mg of trans-1-acetyl-2-(5-nitro-2-fluoro-4-((pyridin-2-carbonyl)-amino)-phenyl)-4-acetoxy-pyrrolidine, and the reaction liquid was stirred at 90° C. for 1 hour. 100 mg of tin(II) chloride dihydrate was added to it, and the reaction liquid was stirred at 90° C. for 5 hours. The reaction liquid was diluted with ethyl acetate, washed with water and saturated saline in order, and dried with anhydrous sodium sulfate. The solvent was evaporated away under reduced pressure to obtain the entitled compound as a yellow oily substance.

1. customthe reaction liquid
2. customthe reaction liquid
3. stirringwas stirred at 90° C. for 5 hours
4. customThe reaction liquid
5. washwashed with water and saturated saline in order
6. dry with materialdried with anhydrous sodium sulfate
7. customThe solvent was evaporated away under reduced pressure
8. customto obtain the entitled compound as a yellow oily substance