Tetrahydrofuran → 5-Bromo-4-chloro-2-methoxymethoxybenzyl alcohol

HRID 133876Notes

Reaction equation

HRID 133876 reaction equation
[Al+3:19].[Br:1][c:2]1[c:3]([Cl:17])[cH:4][c:5]([O:13][CH2:14][O:15][CH3:16])[c:6]([C:7](=[O:8])[O:9][CH2:10][CH3:11])[cH:12]1.[CH2:30]1[O:31][CH2:32][CH2:33][CH2:34]1.[CH3:24][CH2:25][O:26][C:27](=[O:28])[CH3:29].[H-:18].[H-:21].[H-:22].[H-:23].[Li+:20]>>[Br:1][c:2]1[c:3]([Cl:17])[cH:4][c:5]([O:13][CH2:14][O:15][CH3:16])[c:6]([CH2:7][OH:8])[cH:12]1

Participants

7

Reactant 6

HCID 8028TetrahydrofuranHCID 8857Ethyl AcetateHCID 28486Lithium ionHCID 104727Aluminum CationHCID 166653Hydride4×HCID 19701613Ethyl 5-bromo-4-chloro-2-methoxymethoxybenzoate

Product 1

HCID 106128525-Bromo-4-chloro-2-methoxymethoxybenzyl alcohol

Sources & evidence

ORD record
ord-5e2d5b5004a34eab966f4f27f93f14ce
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (9/10)

Reaction notes

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