反应详情

温度

80 °C

1.00 g of 2,6-difluoropyridine is introduced into 10 ml of DMF under nitrogen and 1.44 g of K2CO3 are added at RT. 1.61 g of 4-hydroxy-2-trifluoromethylthiophene are added and the mixture is heated at 80° C. for 4 h, then cooled to RT and poured into water. After extraction twice with heptane/ethyl acetate (1:1) and twice with ethyl acetate the product is washed with water and saturated sodium chloride solution, dried over MgSO4 and concentrated. Chromatographic purification on silica gel with heptane/ethyl acetate (3:7) as eluent gives 1.7 g of 2-fluoro-6-(2-trifluoromethyl-4-thienyloxy)pyridine as a colorless oil.

1. temperaturecooled to RT
2. extractionAfter extraction twice with heptane/ethyl acetate (1:1)
3. washtwice with ethyl acetate the product is washed with water and saturated sodium chloride solution
4. dry with materialdried over MgSO4
5. concentrationconcentrated
6. customChromatographic purification on silica gel with heptane/ethyl acetate (3:7) as eluent