Ammonium formate → HCID 58860672, compound

HRID 1350426Notes

Reaction equation

HRID 1350426 reaction equation
C([N:8]1[CH2:13][CH2:12][NH:11][C@@H:10]([CH2:14][CH2:15][C:16]2[C:25]3[C:20](=[CH:21][CH:22]=[CH:23][CH:24]=3)[CH:19]=[CH:18][CH:17]=2)[CH2:9]1)C1C=CC=CC=1.C([O-])=O.[NH4+]>C(O)C.[OH-].[Pd+2].[OH-]>[C:16]1([CH2:15][CH2:14][C@H:10]2[CH2:9][NH:8][CH2:13][CH2:12][NH:11]2)[C:25]2[C:20](=[CH:21][CH:22]=[CH:23][CH:24]=2)[CH:19]=[CH:18][CH:17]=1

Participants

5

Reactant 2

HCID 2723923Ammonium formateHCID 58860650HCID 58860650, compound

Product 1

HCID 58860672HCID 58860672, compound

Reagents, catalysts & solvents 2

HCID 9942167Palladium hydroxideCatalystHCID 702EthanolSolvent

Procedure

Dissolve (S)-1-benzyl-3-(2-naphthalen-1-yl-ethyl)-piperazine (1.07 g, 3.03 mmol) in ethanol (10 mL). Add ammonium formate (1.2 g, 19.0 mmol) and palladium hydroxide (200 mg, 20 wt. % on carbon) and heat to reflux. After 7 h, filter the palladium hydroxide and concentrate the filtrate. Combine with Example 422 and purify.

Workup

  1. filtrationfilter the palladium hydroxide
  2. concentrationconcentrate the filtrate
  3. customCombine with Example 422 and purify

Sources & evidence

ORD record
ord-1c716cdefb134ebfb19bcedf67c30c31
Source dataset
uspto-grants-2007_05
Patent number
US07214673B2

Reaction notes

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