Trifluoroacetic acid → (4-tert-Butyl-3-fluorophenoxy)acetic acid

HRID 1350823Notes

Reaction equation

HRID 1350823 reaction equation
[C:1]([C:5]1[CH:19]=[CH:18][C:8]([O:9][CH2:10][C:11]([O:13]C(C)(C)C)=[O:12])=[CH:7][C:6]=1[F:20])([CH3:4])([CH3:3])[CH3:2].FC(F)(F)C(O)=O.O1CCCC1>C(Cl)Cl>[C:1]([C:5]1[CH:19]=[CH:18][C:8]([O:9][CH2:10][C:11]([OH:13])=[O:12])=[CH:7][C:6]=1[F:20])([CH3:4])([CH3:2])[CH3:3]

Participants

5

Reactant 3

HCID 6422Trifluoroacetic acidHCID 8028TetrahydrofuranHCID 58640409tert-Butyl (4-tert-butyl-3-fluorophenoxy)acetate

Product 1

HCID 21097504(4-tert-Butyl-3-fluorophenoxy)acetic acidYield 89%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A mixture of tert-butyl (4-tert-butyl-3-fluorophenoxy)acetate (630 mg, 2.2 mmol), trifluoroacetic acid (3.0 ml), tetrahydrofuran (3.0 ml) and methylene dichloride (3.0 ml) was treated in the same procedure described in Example 3(c) to furnish 443 mg of the title compound which was used for further reaction without purification.

Workup

  1. additionwas treated in the same procedure

Sources & evidence

ORD record
ord-70d74d2435274a38909a25e21811e82d
Source dataset
uspto-grants-2007_05
Patent number
US07214824B2

Reaction notes

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