Hydrochloric Acid → HCID 69329379, compound

HRID 1351891Notes

Reaction equation

HRID 1351891 reaction equation
[CH:1]([O:4][C:5]1[CH:41]=[CH:40][C:8]2[CH2:9][CH2:10][CH2:11][CH:12]([N:14](C(OC(C)(C)C)=O)[CH2:15][C@H:16]([O:25][Si](CC)(CC)CC)[CH2:17][O:18][C:19]3[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=3)[CH2:13][C:7]=2[CH:6]=1)([CH3:3])[CH3:2].[ClH:42]>C(OCC)(=O)C>[ClH:42].[CH:1]([O:4][C:5]1[CH:41]=[CH:40][C:8]2[CH2:9][CH2:10][CH2:11][CH:12]([NH:14][CH2:15][C@H:16]([OH:25])[CH2:17][O:18][C:19]3[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=3)[CH2:13][C:7]=2[CH:6]=1)([CH3:3])[CH3:2]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 57129610HCID 57129610, compound

Product 1

HCID 69329379HCID 69329379, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

To N-(3-isopropoxy-6,7,8,9-tetrahydro-5H-benzocyclo-hepten-6-yl)-N-[(2S)-3-phenoxy-2-(triethylsilyloxy)propyl]-tert-butoxycarbonylamine (79 mg) was added 4N hydrogen chloride in ethyl acetate (3 ml) at room temperature, and the mixture was stirred at room temperature for 1 hour. After evaporation in vacuo, the residue was triturated with diisopropyl ether and dried in vacuo to give (2S)-1-(3-isopropoxy-6,7,8,9-tetrahydro-5H-benzocyclohepten-6-yl)amino-3-phenoxy-2-propanol hydrochloride (35 mg). (+) APCI-MASS (m/z): 370 (M-HCl+H)+

Workup

  1. customAfter evaporation in vacuo
  2. customthe residue was triturated with diisopropyl ether
  3. customdried in vacuo

Sources & evidence

ORD record
ord-f41ac6e5eb134163936f5ed9bf347de6
Source dataset
uspto-grants-2007_05
Patent number
US07217706B2

Reaction notes

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