Triethylamine → 2-Fluoro-3-(4-methyl-piperazin-1-yl)-6-nitro-phenylamine

HRID 13519Notes

Reaction equation

HRID 13519 reaction equation
[CH3:1][N:2]1[CH2:7][CH2:6][NH:5][CH2:4][CH2:3]1.CN1C(=O)CCC1.C(N(CC)CC)C.F[C:23]1[CH:24]=[CH:25][C:26]([N+:31]([O-:33])=[O:32])=[C:27]([C:29]=1[F:30])[NH2:28]>O>[F:30][C:29]1[C:23]([N:5]2[CH2:6][CH2:7][N:2]([CH3:1])[CH2:3][CH2:4]2)=[CH:24][CH:25]=[C:26]([N+:31]([O-:33])=[O:32])[C:27]=1[NH2:28]

Participants

6

Reactant 4

HCID 8471TriethylamineHCID 13387N-methyl-2-pyrrolidoneHCID 531671-MethylpiperazineHCID 27370282,3-Difluoro-6-nitroaniline

Product 1

HCID 220408162-Fluoro-3-(4-methyl-piperazin-1-yl)-6-nitro-phenylamine

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A solution of N-methylpiperazine (1.0 eq), NMP, triethylamine (3.0 eq) and 5,6-difluoro-2-nitroaniline (1.0 eq) were heated at 90° C. for 1 hour. The reaction was allowed to cool to room temperature and then poured into water and let stand for 1 hour. The resulting solid was collected and dried and utilized without further purification. MH+=255.3

Workup

  1. customThe resulting solid was collected
  2. customdried
  3. customutilized without further purification

Sources & evidence

ORD record
ord-d7843e8f4929497ebf753b95f50c5b6f
Source dataset
uspto-grants-2010_06
Patent number
US07728010B2

Reaction notes

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