Lithium Hydroxide → HCID 18322853, compound

HRID 1353037Notes

Reaction equation

HRID 1353037 reaction equation
[Li+].[OH-].N(C1C=C(C=CC=1)C([NH:12][CH2:13][C:14]([NH:16][CH:17]([C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1)[CH2:18][C:19]([O:21][CH2:22][CH3:23])=[O:20])=[O:15])=O)C(N)=N.FC(F)(F)C(O)=O>O>[NH2:12][CH2:13][C:14]([NH:16][CH:17]([C:24]1[CH:25]=[CH:26][CH:27]=[CH:28][CH:29]=1)[CH2:18][C:19]([O:21][CH2:22][CH3:23])=[O:20])=[O:15]

Participants

5

Reactant 3

HCID 3939Lithium HydroxideHCID 6422Trifluoroacetic acidHCID 178472103HCID 178472103, compound

Product 1

HCID 18322853HCID 18322853, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

LiOH x H2O (775 mg) was added to a solution of ethyl 3-{2-[(3-(guanidino)benzoyl)amino]acetamido}-3-phenyl-propanoate from II.1-E (2.0 g) in 100 ml of water and the mixture was stirred at room temperature for 1 h. It was then neutralized with trifluoroacetic acid and concentrated. After purification by HPLC, a white solid was obtained (yield: 1.4 g).

Workup

  1. concentrationconcentrated
  2. customAfter purification by HPLC
  3. customa white solid was obtained (yield: 1.4 g)

Sources & evidence

ORD record
ord-545d5ca20bc54575a159d46d064c2c2d
Source dataset
uspto-grants-2007_05
Patent number
US07220824B1

Reaction notes

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