Piperazine → 7-Chloro-4-(piperazin-1-yl)quinoline

HRID 1353308Notes

Reaction equation

HRID 1353308 reaction equation
Cl[C:2]1[C:11]2[C:6](=[CH:7][C:8]([Cl:12])=[CH:9][CH:10]=2)[N:5]=[CH:4][CH:3]=1.[NH:13]1[CH2:18][CH2:17][NH:16][CH2:15][CH2:14]1>CCO>[Cl:12][C:8]1[CH:7]=[C:6]2[C:11]([C:2]([N:13]3[CH2:18][CH2:17][NH:16][CH2:15][CH2:14]3)=[CH:3][CH:4]=[N:5]2)=[CH:10][CH:9]=1

Participants

4

Reactant 2

HCID 4837PiperazineHCID 68664,7-Dichloroquinoline

Product 1

HCID 7383897-Chloro-4-(piperazin-1-yl)quinolineYield 65.4%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

4,7-Dichloroquinoline (9.9 g, 50 mmol) and piperazine (43.1 g, 500 mmol) in EtOH (200 mL) are reacted according to method B yielding 8.10 g of the product.

Sources & evidence

ORD record
ord-ed1fa5c644344a5cafb1740fede11b3f
Source dataset
uspto-grants-2007_05
Patent number
US07220856B2

Reaction notes

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