Cyclobutylamine → HCID 21101798, compound

HRID 1353387Notes

Reaction equation

HRID 1353387 reaction equation
[CH:1]1([NH2:5])[CH2:4][CH2:3][CH2:2]1.Cl[C:7](OC1C=CC([N+]([O-])=O)=CC=1)=[O:8].C(N(C(C)C)CC)(C)C.[Cl:28][C:29]1[CH:38]=[C:37]2[C:32]([C:33]([N:39]3[CH2:44][CH2:43][NH:42][CH2:41][CH2:40]3)=[CH:34][CH:35]=[N:36]2)=[CH:31][CH:30]=1>C(Cl)Cl.CO>[Cl:28][C:29]1[CH:38]=[C:37]2[C:32]([C:33]([N:39]3[CH2:44][CH2:43][N:42]([C:7]([NH:5][CH:1]4[CH2:4][CH2:3][CH2:2]4)=[O:8])[CH2:41][CH2:40]3)=[CH:34][CH:35]=[N:36]2)=[CH:31][CH:30]=1

Participants

6

Reactant 4

HCID 75645CyclobutylamineHCID 81531DiisopropylethylamineHCID 821294-Nitrophenyl chloroformateHCID 7383897-Chloro-4-(piperazin-1-yl)quinoline

Product 1

HCID 21101798HCID 21101798, compound

Reagents, catalysts & solvents 1

HCID 21226129Dichloromethane methanolSolvent

Procedure

As described for example 78, cyclobutylamine (87 mg, 1.21 mmol), 4-nitrophenyl chloroformate (244 mg, 1.21 mmol), diisopropyl(ethyl)amine (2×261 mg, 2×2.02 mmol), and 7-chloro-4-(piperazin-1-yl)quinoline (250 mg, 1.01 mmol) are reacted affording the title product after flash chromatography with CH2Cl2-MeOH.

Workup

  1. customare reacted

Sources & evidence

ORD record
ord-542bd395dfd64ff7b88a4dcdf340c915
Source dataset
uspto-grants-2007_05
Patent number
US07220856B2

Reaction notes

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