Diphenyl N-Cyanocarbonimidate → HCID 87869961, compound

HRID 1353392Notes

Reaction equation

HRID 1353392 reaction equation
[Cl:1][C:2]1[CH:11]=[C:10]2[C:5]([C:6]([N:12]3[CH2:17][CH2:16][NH:15][CH2:14][CH2:13]3)=[CH:7][CH:8]=[N:9]2)=[CH:4][CH:3]=1.[CH:18]1[CH:23]=[CH:22][C:21]([O:24][C:25](OC2C=CC=CC=2)=[N:26][C:27]#[N:28])=[CH:20][CH:19]=1>C1COCC1.CCOCC>[Cl:1][C:2]1[CH:11]=[C:10]2[C:5]([C:6]([N:12]3[CH2:17][CH2:16][N:15]([C:25](=[N:26][C:27]#[N:28])[O:24][C:21]4[CH:22]=[CH:23][CH:18]=[CH:19][CH:20]=4)[CH2:14][CH2:13]3)=[CH:7][CH:8]=[N:9]2)=[CH:4][CH:3]=1

Participants

5

Reactant 2

HCID 688090Diphenyl N-CyanocarbonimidateHCID 7383897-Chloro-4-(piperazin-1-yl)quinoline

Product 1

HCID 87869961HCID 87869961, compound

Reagents, catalysts & solvents 2

HCID 3283Diethyl EtherSolventHCID 8028TetrahydrofuranSolvent

Procedure

7-Chloro-4-(piperazin-1-yl)quinoline (798 mg, 3.22 mmol) and diphenyl cyanocarbonimidate (853 mg, 3.58 mmol) in THF (10 mL) are stirred at room temp. for 15 h. The reaction mixture is diluted with ether, and the precipitate is filtered off to yield the title product as a colorless solid.

Workup

  1. filtrationthe precipitate is filtered off

Sources & evidence

ORD record
ord-039fa00f4bc947349a3166e837a21117
Source dataset
uspto-grants-2007_05
Patent number
US07220856B2

Reaction notes

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