Diisopropylethylamine → HCID 21101724, compound

HRID 1353427Notes

Reaction equation

HRID 1353427 reaction equation
[OH:1][CH:2]1[CH2:8][CH2:7][CH2:6][CH2:5][CH:4]([NH2:9])[CH2:3]1.Cl[C:11](OC1C=CC([N+]([O-])=O)=CC=1)=[O:12].C(N(C(C)C)CC)(C)C.[Cl:32][C:33]1[CH:42]=[C:41]2[C:36]([C:37]([N:43]3[CH2:48][CH2:47][NH:46][CH2:45][CH2:44]3)=[CH:38][CH:39]=[N:40]2)=[CH:35][CH:34]=1>>[Cl:32][C:33]1[CH:42]=[C:41]2[C:36]([C:37]([N:43]3[CH2:48][CH2:47][N:46]([C:11]([NH:9][CH:4]4[CH2:5][CH2:6][CH2:7][CH2:8][CH:2]([OH:1])[CH2:3]4)=[O:12])[CH2:45][CH2:44]3)=[CH:38][CH:39]=[N:40]2)=[CH:35][CH:34]=1

Participants

5

Reactant 4

HCID 81531DiisopropylethylamineHCID 821294-Nitrophenyl chloroformateHCID 7383897-Chloro-4-(piperazin-1-yl)quinolineHCID 20379954HCID 20379954, compound

Product 1

HCID 21101724HCID 21101724, compound

Procedure

As described for example 78, 3-hydroxycycloheptyl-amine, p-nitrophenyl chloroformate, diisopropylethyl amine and 7-chloro-4-piperazinylquinoline are reacted to afford the product. LC-MS: 403 (M++1). 1H NMR (CDCl3) δ 8.75 (d, 1H), 8.05 (s, 1H), 7.96 (d, 1H), 7.45 (d, 1H), 6.84 (d, 1H), 4.50 (d, 1H), 4.10 (m, 2H), 3.65 (m, 4H), 3.20 (m, 4H), 2.38 (m, 1H), 2.0 (m, 3H), 1.80 (m, 4H), 1.40 (m, 2H).

Workup

  1. customare reacted
  2. customto afford the product

Sources & evidence

ORD record
ord-f816b9041c754cef82358d856a818454
Source dataset
uspto-grants-2007_05
Patent number
US07220856B2

Reaction notes

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