Diisopropylethylamine → HCID 58864150, compound

HRID 1353459Notes

Reaction equation

HRID 1353459 reaction equation
Cl[C:2]([O:4][C:5]1[CH:10]=[CH:9][C:8]([N+:11]([O-:13])=[O:12])=[CH:7][CH:6]=1)=[O:3].C(N(C(C)C)CC)(C)C.[Cl:23][C:24]1[CH:33]=[C:32]2[C:27]([C:28]([N:35]3[CH2:40][CH2:39][NH:38][CH2:37][CH2:36]3)=[CH:29][C:30]([NH2:34])=[N:31]2)=[CH:26][CH:25]=1>>[NH2:34][C:30]1[CH:29]=[C:28]([N:35]2[CH2:36][CH2:37][N:38]([C:2]([O:4][C:5]3[CH:10]=[CH:9][C:8]([N+:11]([O-:13])=[O:12])=[CH:7][CH:6]=3)=[O:3])[CH2:39][CH2:40]2)[C:27]2[C:32](=[CH:33][C:24]([Cl:23])=[CH:25][CH:26]=2)[N:31]=1

Participants

4

Reactant 3

HCID 81531DiisopropylethylamineHCID 821294-Nitrophenyl chloroformateHCID 211017487-Chloro-4-(1-piperazinyl)-2-quinolinamine

Product 1

HCID 58864150HCID 58864150, compound

Procedure

As described for example 78, 7-chloro-4-aminoqunoline, p-nitrophenyl chloroformate, diisopropylethyl amine, and 7-chloro-4-(1-piperazinyl)-2-quinolinamine are reacted to afford the product. LC-MS: 427 (M++1). 1H NMR (DMSO-d6) δ 3.0–3.2 (m, 4H), 3.6–3.9 (m, 4H), 6.2–6.3 (s, 1H), 6.4–6.6 (s, H), 7.05–7.2 (m, 1H), 7.35–7.4 (m, 1H), 7.4–7.5 (d, 2H), 7.7–7.8 (d, 1H), 8.2–8.35 (d, 2H).

Workup

  1. customare reacted
  2. customto afford the product

Sources & evidence

ORD record
ord-7f007471329a40ef9bb9912908fc2ab8
Source dataset
uspto-grants-2007_05
Patent number
US07220856B2

Reaction notes

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