Diisopropylethylamine → HCID 72447322, compound

HRID 1353460Notes

Reaction equation

HRID 1353460 reaction equation
[CH3:1][O:2][C:3]([CH:5]1[CH2:11][CH2:10][CH2:9][CH2:8][CH2:7][C:6]1=[N:12][OH:13])=[O:4].Cl[C:15](OC1C=CC([N+]([O-])=O)=CC=1)=[O:16].C(N(C(C)C)CC)(C)C.[Cl:36][C:37]1[CH:46]=[C:45]2[C:40]([C:41]([N:48]3[CH2:53][CH2:52][NH:51][CH2:50][CH2:49]3)=[CH:42][C:43]([NH2:47])=[N:44]2)=[CH:39][CH:38]=1>>[NH2:47][C:43]1[CH:42]=[C:41]([N:48]2[CH2:53][CH2:52][N:51]([C:15]([O:13][N:12]=[C:6]3[CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH:5]3[C:3]([O:2][CH3:1])=[O:4])=[O:16])[CH2:50][CH2:49]2)[C:40]2[C:45](=[CH:46][C:37]([Cl:36])=[CH:38][CH:39]=2)[N:44]=1

Participants

5

Reactant 4

HCID 81531DiisopropylethylamineHCID 821294-Nitrophenyl chloroformateHCID 211017487-Chloro-4-(1-piperazinyl)-2-quinolinamineHCID 85912753HCID 85912753, compound

Product 1

HCID 72447322HCID 72447322, compound

Procedure

As described for 78, 2-methoxycarbonyl-cycloheptanone-oxime, 4-nitrophenyl chloroformate, diisopropyl(ethyl)amine, and 7-chloro-4-(1-piperazinyl)-2-quinolinamine are reacted to afford the product. LC-MS: 474 (M++1). 1H NMR (CDCl3) δ 7.75 (d, 1H), 7.60 (s, 1H), 7.18 (d, 1H), 6.15 (s, 1H), 4.80 (s, 2H), 3.80 (m, 5H), 3.75 (s, 3H), 3.15 (m, 4H), 2.90 (m, 1H), 2.40 (m, 1H), 2.05 (m, 2H), 1.72 (m, 2H), 1.60 (m, 3H), 1.45 (m, 1H).

Workup

  1. customare reacted
  2. customto afford the product

Sources & evidence

ORD record
ord-d6e771d67eed4ef1b9cb1b49621681b0
Source dataset
uspto-grants-2007_05
Patent number
US07220856B2

Reaction notes

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