Diisopropylethylamine → HCID 58864160, compound

HRID 1353461Notes

Reaction equation

HRID 1353461 reaction equation
[CH3:1][O:2][C:3]([CH:5]1[CH2:11][CH2:10][CH2:9][CH2:8][CH2:7][CH:6]1[NH2:12])=[O:4].Cl[C:14](OC1C=CC([N+]([O-])=O)=CC=1)=[O:15].C(N(C(C)C)CC)(C)C.[Cl:35][C:36]1[CH:45]=[C:44]2[C:39]([C:40]([N:47]3[CH2:52][CH2:51][NH:50][CH2:49][CH2:48]3)=[CH:41][C:42]([NH2:46])=[N:43]2)=[CH:38][CH:37]=1>>[NH2:46][C:42]1[CH:41]=[C:40]([N:47]2[CH2:52][CH2:51][N:50]([C:14]([NH:12][CH:6]3[CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH:5]3[C:3]([O:2][CH3:1])=[O:4])=[O:15])[CH2:49][CH2:48]2)[C:39]2[C:44](=[CH:45][C:36]([Cl:35])=[CH:37][CH:38]=2)[N:43]=1

Participants

5

Reactant 4

HCID 81531DiisopropylethylamineHCID 821294-Nitrophenyl chloroformateHCID 4650515Methyl 2-aminocycloheptane-1-carboxylateHCID 211017487-Chloro-4-(1-piperazinyl)-2-quinolinamine

Product 1

HCID 58864160HCID 58864160, compound

Procedure

As described for 78, 2-methoxycarbonyl cycloheptyl amine, 4-nitrophenyl chloroformate, diisopropyl(ethyl)amine, and 7-chloro-4-(1-piperazinyl)-2-quinolinamine are reacted to afford the product. LC-MS: 460 (M++1). 1H NMR (CDCl3) δ 7.72 (d, 1H), 7.60 (s, 1H), 7.18 (d, 1H), 6.15 (s, 1H), 5.50 (d, 1H), 4.70 (s, 2H), 4.15 (m, 1H), 3.70 (s, 3H), 3.60 (m, 4H), 3.10 (m, 4H), 2.95 (m, 1H), 2.00 (m, 1H), 1.85 (m, 3H), 1.65 (m, 5H), 1.45 (m, 1H).

Workup

  1. customare reacted
  2. customto afford the product

Sources & evidence

ORD record
ord-9f8368ea4a834c1c8a7a22ad3723cc01
Source dataset
uspto-grants-2007_05
Patent number
US07220856B2

Reaction notes

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