Cycloheptylamine → HCID 21101679, compound

HRID 1353465Notes

Reaction equation

HRID 1353465 reaction equation
[CH:1]1([NH2:8])[CH2:7][CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.Cl[C:10](OC1C=CC([N+]([O-])=O)=CC=1)=[O:11].C(N(C(C)C)CC)(C)C.[Cl:31][C:32]1[CH:41]=[C:40]2[C:35]([C:36]([N:43]3[CH2:48][CH2:47][NH:46][CH2:45][CH2:44]3)=[CH:37][C:38]([NH2:42])=[N:39]2)=[CH:34][CH:33]=1>>[NH2:42][C:38]1[CH:37]=[C:36]([N:43]2[CH2:48][CH2:47][N:46]([C:10]([NH:8][CH:1]3[CH2:7][CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]3)=[O:11])[CH2:45][CH2:44]2)[C:35]2[C:40](=[CH:41][C:32]([Cl:31])=[CH:33][CH:34]=2)[N:39]=1

Participants

5

Reactant 4

HCID 2899CycloheptylamineHCID 81531DiisopropylethylamineHCID 821294-Nitrophenyl chloroformateHCID 211017487-Chloro-4-(1-piperazinyl)-2-quinolinamine

Product 1

HCID 21101679HCID 21101679, compound

Procedure

As described for example 78, cycloheptylamine, 4-nitrophenyl chloroformate, diisopropyl(ethyl)amine, and 7-chloro-4-(1-piperazinyl)-2-quinolinamine are reacted to afford the product as a light yellow solid. LC-MS: 402 (M++1). 1H NMR (CDCl3) δ 7.75 (d, 1H), 7.62 (s, 1H), 7.15 (d, 1H), 6.15 (s, 1H), 4.78 (s, 2H), 4.40 (d, 1H), 3.90 (m, 1H), 3.60 (m, 4H), 3.10 (m, 4H), 1.95 (m, 2H) 1.40–1.65 (m, 10H).

Workup

  1. customare reacted

Sources & evidence

ORD record
ord-ee413002eb6f4256baf432789e60159e
Source dataset
uspto-grants-2007_05
Patent number
US07220856B2

Reaction notes

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