Diisopropylethylamine → HCID 21101676, compound

HRID 1353466Notes

Reaction equation

HRID 1353466 reaction equation
[F:1][C:2]1[CH:8]=[CH:7][C:5]([NH2:6])=[CH:4][C:3]=1[O:9][CH3:10].Cl[C:12](OC1C=CC([N+]([O-])=O)=CC=1)=[O:13].C(N(C(C)C)CC)(C)C.[Cl:33][C:34]1[CH:43]=[C:42]2[C:37]([C:38]([N:45]3[CH2:50][CH2:49][NH:48][CH2:47][CH2:46]3)=[CH:39][C:40]([NH2:44])=[N:41]2)=[CH:36][CH:35]=1>>[NH2:44][C:40]1[CH:39]=[C:38]([N:45]2[CH2:50][CH2:49][N:48]([C:12]([NH:6][C:5]3[CH:7]=[CH:8][C:2]([F:1])=[C:3]([O:9][CH3:10])[CH:4]=3)=[O:13])[CH2:47][CH2:46]2)[C:37]2[C:42](=[CH:43][C:34]([Cl:33])=[CH:35][CH:36]=2)[N:41]=1

Participants

5

Reactant 4

HCID 81531DiisopropylethylamineHCID 821294-Nitrophenyl chloroformateHCID 27745334-Fluoro-3-methoxyanilineHCID 211017487-Chloro-4-(1-piperazinyl)-2-quinolinamine

Product 1

HCID 21101676HCID 21101676, compound

Procedure

As described for example 78, 4-fluoro-3-methoxy-aniline, 4-nitrophenyl chloroformate, diisopropyl(ethyl)amine, and 7-chloro-4-(1-piperazinyl)-2-quinolinamine are reacted to afford the product as a light yellow solid. LC-MS: 430 (M++1). 1H NMR (CD3OD) δ 8.25 (m, 2H), 7.82 (m, 1H), 7.45 (s, 1H), 7.40 (d, 2H), 7.20 (d, 1H), 6.40 (s, 1H), 3.95 (s, 3H), 3.80 (m, 4H), 3.25 (m, 4H).

Workup

  1. customare reacted

Sources & evidence

ORD record
ord-fb371bac2eb546f0be942817403b6ee8
Source dataset
uspto-grants-2007_05
Patent number
US07220856B2

Reaction notes

Loading…