Diisopropylethylamine → HCID 21101664, compound

HRID 1353468Notes

Reaction equation

HRID 1353468 reaction equation
[NH2:1][C:2]1[C:3](=[O:9])[N:4]([CH3:8])[CH:5]=[CH:6][CH:7]=1.Cl[C:11](OC1C=CC([N+]([O-])=O)=CC=1)=[O:12].C(N(C(C)C)CC)(C)C.[Cl:32][C:33]1[CH:42]=[C:41]2[C:36]([C:37]([N:44]3[CH2:49][CH2:48][NH:47][CH2:46][CH2:45]3)=[CH:38][C:39]([NH2:43])=[N:40]2)=[CH:35][CH:34]=1>>[NH2:43][C:39]1[CH:38]=[C:37]([N:44]2[CH2:49][CH2:48][N:47]([C:11]([NH:1][C:2]3[C:3](=[O:9])[N:4]([CH3:8])[CH:5]=[CH:6][CH:7]=3)=[O:12])[CH2:46][CH2:45]2)[C:36]2[C:41](=[CH:42][C:33]([Cl:32])=[CH:34][CH:35]=2)[N:40]=1

Participants

5

Reactant 4

HCID 81531DiisopropylethylamineHCID 821294-Nitrophenyl chloroformateHCID 156922083-Amino-1-methylpyridin-2(1H)-oneHCID 211017487-Chloro-4-(1-piperazinyl)-2-quinolinamine

Product 1

HCID 21101664HCID 21101664, compound

Procedure

As described for example 78, 3-amino-1-methyl-2-pyridone, 4-nitrophenyl chloroformate, diisopropyl(ethyl)amine, and 7-chloro-4-(1-piperazinyl)-2-quinolinamine are reacted to afford the product. LC-MS: 413 (M++1). 1H NMR (CDCl3) δ 8.15 (dd, 1H), 8.02 (s, 1H), 7.74 (d, 1H), 7.65 (s, 1H), 7.20 (dd, 1H), 6.95 (dd, 1H), 6.25 (m, 1H), 6.16 (s, 1H), 5.00 (s, 2H), 3.80 (m, 4H), 3.62 (s, 3H), 3.20 (m, 4H).

Workup

  1. customare reacted
  2. customto afford the product

Sources & evidence

ORD record
ord-cbf4763715dc401ca0721816eb621c0b
Source dataset
uspto-grants-2007_05
Patent number
US07220856B2

Reaction notes

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