Diisopropylethylamine → HCID 86591808, compound

HRID 1353470Notes

Reaction equation

HRID 1353470 reaction equation
[CH3:1][O:2][C:3]([CH:5]1[CH2:10][CH2:9][CH2:8][CH2:7][CH:6]1N)=[O:4].ClC(OC1C=CC([N+]([O-])=O)=CC=1)=[O:14].C([N:28]([CH:31](C)C)CC)(C)C.[Cl:34][C:35]1[CH:44]=[C:43]2[C:38]([C:39]([N:46]3[CH2:51][CH2:50][NH:49][CH2:48][CH2:47]3)=[CH:40][C:41]([NH2:45])=[N:42]2)=[CH:37][CH:36]=1>>[NH2:45][C:41]1[CH:40]=[C:39]([N:46]2[CH2:51][CH2:50][N:49]([C:31]([NH:28][CH:7]3[CH2:8][CH2:9][CH2:10][CH:5]([C:3]([O:2][CH3:1])=[O:4])[CH2:6]3)=[O:14])[CH2:48][CH2:47]2)[C:38]2[C:43](=[CH:44][C:35]([Cl:34])=[CH:36][CH:37]=2)[N:42]=1

Participants

5

Reactant 4

HCID 81531DiisopropylethylamineHCID 821294-Nitrophenyl chloroformateHCID 16639469Methyl 2-aminocyclohexane-1-carboxylateHCID 211017487-Chloro-4-(1-piperazinyl)-2-quinolinamine

Product 1

HCID 86591808HCID 86591808, compound

Procedure

As described for example 78, 2-amino-cyclohexanecarboxylic acid-methyl ester, 4-nitrophenyl chloroformate, diisopropyl(ethyl)amine, and 7-chloro-4-(1-piperazinyl)-2-quinolinamine are reacted to afford the product as a light yellow solid. LC-MS: 446 (M++1). 1H NMR (CD3OD) δ 1.20–1.40 (m, 4H), 1.90 (m, 3H), 2.10 (m, 1H), 2.45 (m, 1H), 3.30 (m, 4H), 3.70 (m, 8H), 6.35 (s, 1H), 7.38 (d, 1H), 7.60 (s, 1H), 790 (d, 1H).

Workup

  1. customare reacted

Sources & evidence

ORD record
ord-62ca934868754588b351a51cac37d5a1
Source dataset
uspto-grants-2007_05
Patent number
US07220856B2

Reaction notes

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