Neopentyl alcohol → HCID 17979113, compound

In 4 ml of tetrahydrofuran was suspended 0.10 g of sodium hydride (60% in oil), to which 0.5 ml of tetrahydrofuran containing 0.14 g of 2,2-dimethyl-1-propanol dissolved therein was added dropwise at room temperature, followed by stirring for 10 minutes. To this was added dropwise 0.5 ml of tetrahydrofuran containing 0.3 g of 4,6-dichloropyrimidine dissolved therein at 0° C., followed by stirring at the same temperature for 4 hours. The reaction mixture was then poured into a saturated aqueous ammonium chloride solution, which was extracted three times with t-butyl methyl ether. The combined organic layers were washed with a saturated aqueous sodium chloride solution, dried over anhydrous magnesium sulfate, and then concentrated. The residue was subjected to silica gel column chromatography to give 0.16 g of 4-chloro-6-(2,2-dimethylpropyloxy)pyrimidine.

1. additiontherein was added dropwise at room temperature
2. dissolutiondissolved
3. customat 0° C.
4. stirringby stirring at the same temperature for 4 hours
5. extractionwas extracted three times with t-butyl methyl ether
6. washThe combined organic layers were washed with a saturated aqueous sodium chloride solution
7. dry with materialdried over anhydrous magnesium sulfate
8. concentrationconcentrated

ORD record

ord-e84410401dde484c9117e5d332b75559

Source dataset

uspto-grants-2007_05

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US07223769B2