Acetoxyacetyl chloride → HCID 21104418, compound

HRID 1354179Notes

Reaction equation

HRID 1354179 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([C:8]2[C:20]([C:21]3[CH:26]=[CH:25][C:24]([S:27]([NH2:30])(=[O:29])=[O:28])=[CH:23][CH:22]=3)=[C:11]3[CH:12]=[CH:13][C:14]([C:16]([F:19])([F:18])[F:17])=[CH:15][N:10]3[N:9]=2)[CH:5]=[CH:6][CH:7]=1.[C:31]([O:34][CH2:35][C:36](Cl)=[O:37])(=[O:33])[CH3:32]>CN(C)C1C=CN=CC=1.C(N(C(C)C)CC)(C)C>[C:31]([O:34][CH2:35][C:36]([NH:30][S:27]([C:24]1[CH:25]=[CH:26][C:21]([C:20]2[C:8]([C:4]3[CH:5]=[CH:6][CH:7]=[C:2]([F:1])[CH:3]=3)=[N:9][N:10]3[CH:15]=[C:14]([C:16]([F:17])([F:18])[F:19])[CH:13]=[CH:12][C:11]=23)=[CH:22][CH:23]=1)(=[O:29])=[O:28])=[O:37])(=[O:33])[CH3:32]

Participants

5

Reactant 2

HCID 26297Acetoxyacetyl chlorideHCID 9845828HCID 9845828, compound

Product 1

HCID 21104418HCID 21104418, compound

Reagents, catalysts & solvents 2

HCID 142844-(Dimethylamino)pyridineCatalystHCID 81531DiisopropylethylamineSolvent

Procedure

By using 4-[2-(3-fluoro-phenyl)-6-trifluoromethyl-pyrazolo[1,5-a]pyridin-3-yl]benzenesulfonamide (0.15 g 0.35 mmol), diisopropylethylamine (Aldrich) (150 μl ), 4-dimethylaminopyridine (0.04 g 0.32 mmol) and acetoxyacetyl chloride (Aldrich) (0.109 g 0.8 mmol), the title compound was obtained in the manner of Example 19 as a white solid (0.14 g 75%).

Sources & evidence

ORD record
ord-3eafc36aa09441ad833a0c60e782a578
Source dataset
uspto-grants-2007_05
Patent number
US07223772B1

Reaction notes

Loading…