Potassium Carbonate → HCID 21105543, compound

HRID 1354725Notes

Reaction equation

HRID 1354725 reaction equation
C(=O)([O-])[O-].[K+].[K+].[F:7][C:8]1[CH:9]=[C:10]([CH:15]=[CH:16][C:17]=1F)[C:11]([O:13][CH3:14])=[O:12].[CH3:19][CH:20]1[CH2:25][CH2:24][NH:23][CH2:22][CH2:21]1>CN(C=O)C>[F:7][C:8]1[CH:9]=[C:10]([CH:15]=[CH:16][C:17]=1[N:23]1[CH2:24][CH2:25][CH:20]([CH3:19])[CH2:21][CH2:22]1)[C:11]([O:13][CH3:14])=[O:12]

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 693814-MethylpiperidineHCID 2775358Methyl 3,4-difluorobenzoate

Product 1

HCID 21105543HCID 21105543, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Conditions

Temperature
60 °C

Procedure

0.076 g of potassium carbonate was added to a solution of 0.086 g of methyl 3,4-difluorobenzoate and 0.050 g of 4-methylpiperidine in 0.5 ml of DMF. The reaction was heated at 60° C. for 2 days, filtered and purified by preparative HPLC. This resulted in the product with the molecular weight of 251.3 (C14H18FNO2); MS (ESI): 252 (M+H+) as hydrotrifluoroacetate.

Workup

  1. filtrationfiltered
  2. custompurified by preparative HPLC
  3. customThis resulted in the product with the molecular weight of 251.3 (C14H18FNO2)

Sources & evidence

ORD record
ord-2e57276745b446d7a01c74e7811619f6
Source dataset
uspto-grants-2007_05
Patent number
US07223788B2

Reaction notes

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