反应详情

温度

140 °C

49 mg of potassium carbonate were added to a solution of 0.041 g of 6-chloro-N-[4-(3-dimethylaminopyrrolidin-1-yl)phenyl]nicotinamide and 4-fluorophenol (30 mg) in 0.8 ml of DMF, and the reaction was heated at 140° C. in a microwave apparatus for 90 minutes. After addition of water and ethyl acetate, the aqueous phase was extracted three times with ethyl acetate. The combined organic phases were dried over sodium sulfate, concentrated in vacuo and purified by preparative HPLC. This resulted in the product with the molecular weight of 420.2 (C24H25FN4O2); MS (ESI): 421 (M+H+) as hydrotrifluoroacetate.

1. extractionthe aqueous phase was extracted three times with ethyl acetate
2. dry with materialThe combined organic phases were dried over sodium sulfate
3. concentrationconcentrated in vacuo
4. custompurified by preparative HPLC
5. customThis resulted in the product with the molecular weight of 420.2 (C24H25FN4O2)