反应详情

温度

90 °C

Sodium hydride (50% in oil, 250 mg) was added to benzhydryl 5-hydroxypyridine-2-carboxylate (2.0 g) dissolved in DMF (20 ml) and, after gas evolution ceased, 1-bromobutane (0.72 g) was added. The mixture was heated at 90° C. for 6 hours. It was diluted with water and extracted with ethyl acetate. The organic phase was dried over magnesium sulfate and concentrated. The residue was hydrogenated in analogy to method B. This resulted in the product with the molecular weight of 195.22 (C10H13NO3); MS (ESI): 196 (M+H+).

1. extractionextracted with ethyl acetate
2. dry with materialThe organic phase was dried over magnesium sulfate
3. concentrationconcentrated
4. customThis resulted in the product with the molecular weight of 195.22 (C10H13NO3)