反应详情

Sodium hydride (50% in oil; 0.42 g) was cautiously added to a solution of propanol (0.6 g) in DMF (8 ml). After gas evolution ceased, methyl 4-bromomethylbenzoate (1.0 g) was added. After 4 hours, the mixture was partitioned between water and ethyl acetate. The organic phase was dried over magnesium sulfate and concentrated. The residue was hydrolyzed by method P-a. This resulted in the product with the molecular weight of 194.23 (C11H14O3); MS (ESI): 195 (M+H+).

1. customthe mixture was partitioned between water and ethyl acetate
2. dry with materialThe organic phase was dried over magnesium sulfate
3. concentrationconcentrated
4. customThis resulted in the product with the molecular weight of 194.23 (C11H14O3)