Benzyl Bromide → 2-Amino-4-benzylsulfanyl-6-phenyl-pyrimidine-5-carbonitrile

HRID 1355716Notes

Reaction equation

HRID 1355716 reaction equation
[NH2:1][C:2]1[NH:3][C:4](=[S:16])[C:5]([C:14]#[N:15])=[C:6]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)[N:7]=1.[CH2:17](Br)[C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1.CC[O-].[Na+]>C(O)C>[NH2:1][C:2]1[N:3]=[C:4]([S:16][CH2:17][C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)[C:5]([C:14]#[N:15])=[C:6]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)[N:7]=1

Participants

5

Reactant 3

HCID 7498Benzyl BromideHCID 2723922Sodium ethoxideHCID 178509378HCID 178509378, compound

Product 1

HCID 185075682-Amino-4-benzylsulfanyl-6-phenyl-pyrimidine-5-carbonitrile

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

From 2-amino-4-phenyl-6-thioxo-1,6-dihydro-pyrimidine-5-carbonitrile, benzyl bromide and sodium ethylate in ethanol. EI-MS m/e (%):318 (M+, 50), 317 ([M—H]+, 100), 285 (20), 91 (84).

Sources & evidence

ORD record
ord-59c9a145e7fa4e97a23af9025db4a083
Source dataset
uspto-grants-2003_07
Patent number
US06586441B2

Reaction notes

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