Butyl bromide → 2-Amino-4-butylsulfanyl-6-phenyl-pyrimidine-5-carbonitrile

HRID 1355719Notes

Reaction equation

HRID 1355719 reaction equation
[NH2:1][C:2]1[NH:3][C:4](=[S:16])[C:5]([C:14]#[N:15])=[C:6]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)[N:7]=1.[CH2:17](Br)[CH2:18][CH2:19][CH3:20].CC[O-].[Na+]>C(O)C>[NH2:1][C:2]1[N:3]=[C:4]([S:16][CH2:17][CH2:18][CH2:19][CH3:20])[C:5]([C:14]#[N:15])=[C:6]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)[N:7]=1

Participants

5

Reactant 3

HCID 8002Butyl bromideHCID 2723922Sodium ethoxideHCID 178509378HCID 178509378, compound

Product 1

HCID 185076722-Amino-4-butylsulfanyl-6-phenyl-pyrimidine-5-carbonitrile

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

From 2-amino-4-phenyl-6-thioxo-1,6-dihydro-pyrimidine-5-carbonitrile, butyl bromide and sodium ethylate in ethanol. EI-MS m/e (%): 284 (M+, 48), 283 ([M—H]+, 100), 241 (([M—C3H7]+, 95), 228 (([M—C2H5CH═CH2]+, 92).

Sources & evidence

ORD record
ord-838201fbb8d44b8b8ccfd24ca6fa4b4d
Source dataset
uspto-grants-2003_07
Patent number
US06586441B2

Reaction notes

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