Piconol → HCID 9944478, compound

HRID 1355882Notes

Reaction equation

HRID 1355882 reaction equation
[NH2:1][C:2]1[N:7]=[C:6](S(C)=O)[C:5]([C:11]#[N:12])=[C:4]([C:13]2[S:14][CH:15]=[CH:16][CH:17]=2)[N:3]=1.[OH:18][CH2:19][C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][N:21]=1.C1CCN2C(=NCCC2)CC1>O1CCOCC1>[NH2:1][C:2]1[N:7]=[C:6]([O:18][CH2:19][C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][N:21]=2)[C:5]([C:11]#[N:12])=[C:4]([C:13]2[S:14][CH:15]=[CH:16][CH:17]=2)[N:3]=1

Participants

5

Reactant 3

HCID 11474PiconolHCID 811841,8-Diazabicyclo(5.4.0)undec-7-eneHCID 18507414HCID 18507414, compound

Product 1

HCID 9944478HCID 9944478, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

From 2-amino-4-methanesulfinyl-6-thiophen-2-yl-pyrimidine-5-carbonitrile, 2-(hydroxymethyl)pyridine and DBU in dioxane. EI-MS m/e (%): 309 (M+, 53), 308 ([M—H]+, 48), 292 ([M—NH3]+, 32), 108 (100), 92 (50), 65 (49).

Sources & evidence

ORD record
ord-83e49589b1d044d4a464fb64b752523d
Source dataset
uspto-grants-2003_07
Patent number
US06586441B2

Reaction notes

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