Chlorosuccinimide → 2-Amino-4-(5-chloro-furan-2-yl)-6-(3,5-dimethyl-pyridin-2-ylmethoxy)-pyrimidine-5-carbonitrile

HRID 1356188Notes

Reaction equation

HRID 1356188 reaction equation
[NH2:1][C:2]1[N:7]=[C:6]([O:8][CH2:9][C:10]2[C:15]([CH3:16])=[CH:14][C:13]([CH3:17])=[CH:12][N:11]=2)[C:5]([C:18]#[N:19])=[C:4]([C:20]2[O:21][CH:22]=[CH:23][CH:24]=2)[N:3]=1.[Cl:25]N1C(=O)CCC1=O>CN(C=O)C>[NH2:1][C:2]1[N:3]=[C:4]([C:20]2[O:21][C:22]([Cl:25])=[CH:23][CH:24]=2)[C:5]([C:18]#[N:19])=[C:6]([O:8][CH2:9][C:10]2[C:15]([CH3:16])=[CH:14][C:13]([CH3:17])=[CH:12][N:11]=2)[N:7]=1

Participants

4

Reactant 2

HCID 31398ChlorosuccinimideHCID 98801462-Amino-4-(3,5-dimethyl-pyridin-2-ylmethoxy)-6-furan-2-yl-pyrimidine-5-carbonitrile

Product 1

HCID 101088962-Amino-4-(5-chloro-furan-2-yl)-6-(3,5-dimethyl-pyridin-2-ylmethoxy)-pyrimidine-5-carbonitrile

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

From 2-amino-4-(3,5-dimethyl-pyridin-2-ylmethoxy)-6-furan-2-yl-pyrimidine-5-carbonitrile and N-chlorosuccinimide in DMF. ES-MS m/e (%): 358 (M{37Cl}+H+, 30), 356 (M{35Cl}+H+, 100).

Sources & evidence

ORD record
ord-3a40bda8dcbd440ebaaacfe50040d709
Source dataset
uspto-grants-2003_07
Patent number
US06586441B2

Reaction notes

Loading…