Ethylamine hydrochloride → 3'-(N-Ethylaminomethyl)acetophenone

HRID 1356819Notes

Reaction equation

HRID 1356819 reaction equation
Cl.[CH2:2]([NH2:4])[CH3:3].[OH-].[Na+].Br[CH2:8][C:9]1[CH:10]=[C:11]([C:15](=[O:17])[CH3:16])[CH:12]=[CH:13][CH:14]=1>C(N(CC)CC)C>[CH2:2]([NH:4][CH2:8][C:9]1[CH:10]=[C:11]([C:15](=[O:17])[CH3:16])[CH:12]=[CH:13][CH:14]=1)[CH3:3]

Participants

5

Reactant 3

HCID 11198Ethylamine hydrochlorideHCID 14798Sodium HydroxideHCID 154798071-(3-(Bromomethyl)phenyl)ethan-1-one

Product 1

HCID 185094903'-(N-Ethylaminomethyl)acetophenoneYield 66.7%

Reagents, catalysts & solvents 1

HCID 8471TriethylamineSolvent

Procedure

The procedure described in Referential Example 4 was repeated, except that ethylamine hydrochloride (16.31 g; 200 mmol), sodium hydroxide (instead of triethylamine) (8 g; 200 mmol), and 3′-bromomethylacetophenone (4.26 g; 20 mmol) were used, to thereby yield 2.36 g of the target compound (yield: 66.7%).

Sources & evidence

ORD record
ord-6495665b67df4ae2bce83b3239720d0a
Source dataset
uspto-grants-2003_07
Patent number
US06586633B1

Reaction notes

Loading…