1,2-Dibromoethane → HCID 18505222, compound

HRID 1357055Notes

Reaction equation

HRID 1357055 reaction equation
[Br:1][CH2:2][CH2:3]Br.[NH:5]1[C:13]2[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=2)[CH2:7][CH2:6]1.C(N(CC)CC)C>C(OCC)(=O)C>[Br:1][CH2:2][CH2:3][N:5]1[C:13]2[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=2)[CH2:7][CH2:6]1

Participants

5

Reactant 3

HCID 78391,2-DibromoethaneHCID 8471TriethylamineHCID 10328Indoline

Product 1

HCID 18505222HCID 18505222, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Conditions

Temperature
90 °C

Procedure

To 1,2-dibromoethane (58.0 ml) were added indoline (5.0 g) and triethylamine (28.7 ml), and the mixture was stirred at 90° C. for 2 hr. Ethyl acetate (200 ml) was added to the reaction mixture, and the mixture was washed with saturated brine (400 ml) and dried over Na2SO4. Ethyl acetate was evaporated under reduced pressure. The obtained residue was purified by column chromatography to give the title compound (4.09 g).

Workup

  1. washthe mixture was washed with saturated brine (400 ml)
  2. dry with materialdried over Na2SO4
  3. customEthyl acetate was evaporated under reduced pressure
  4. customThe obtained residue was purified by column chromatography

Sources & evidence

ORD record
ord-3e7034e9380546e18d51bb346408ad52
Source dataset
uspto-grants-2003_07
Patent number
US06589963B2

Reaction notes

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