反应详情

Triethylamine (606 mg) was added to a solution of 3,5-dimethyl-6-hydroxymethyl-4-methoxymethoxy-2H-pyran-2-one (1.26 g) in THF (50 ml), and after stirring the mixture at room temperature for one hour, methanesulfonyl chloride (1.05 g) was added and the mixture was stirred at room temperature overnight. Water was added to the reaction solution, extraction was performed with AcOEt, and the organic layer was dried with Na2SO4 and then filtered and concentrated. The residue was purified by silica gel column chromatography (n-hexane/AcOEt=1/1) to obtain 3,5-dimethyl-4-methoxymethoxy-6-(methylsulfonyloxy) methyl-2H-pyran-2-one.

1. stirringthe mixture was stirred at room temperature overnight
2. dry with materialthe organic layer was dried with Na2SO4
3. filtrationfiltered
4. concentrationconcentrated
5. customThe residue was purified by silica gel column chromatography (n-hexane/AcOEt=1/1)