Hydrochloric Acid → 2-Hydroxy-4-morpholin-4-yl-benzaldehyde
Reaction equation
[O:1]1[CH2:6][CH2:5][N:4]([C:7]2[CH:8]=[C:9]([OH:13])[CH:10]=[CH:11][CH:12]=2)[CH2:3][CH2:2]1.C([Mg]Br)C.[CH2:18]=[O:19].Cl>C1COCC1.CCN(CC)CC.C(OCC)C>[OH:13][C:9]1[CH:8]=[C:7]([N:4]2[CH2:3][CH2:2][O:1][CH2:6][CH2:5]2)[CH:12]=[CH:11][C:10]=1[CH:18]=[O:19]Participants
Reactant 4
Product 1
Reagents, catalysts & solvents 3
Conditions
- Temperature
- 30 °C
Procedure
After slowly adding a solution of 3-morpholinophenol (5.0 g) in THF (100 ml) to a 3 M diethyl ether solution (10 ml) of ethylmagnesium bromide, the mixture was stirred at 30° C. for 1.5 hours. Paraformaldehyde (3.0 g) and Et3N (3.0 g) were added to the reaction solution and the mixture was stirred at 80° C. for 4 hours. After cooling, a 6 N hydrochloric acid aqueous solution (20 ml) was added, the mixture was stirred for an hour, and then the organic layer and aqueous layer were separated and the aqueous layer was rendered weakly alkaline prior to extraction with AcOEt. The organic layers were combined and dried with MgSO4, and then filtered and concentrated. The residue was purified by silica gel column chromatography (n-hexane/AcOEt=3/1) to obtain 2-hydroxy-4-morpholinobenzaldehyde.
Workup
- stirringthe mixture was stirred at 80° C. for 4 hours
- temperatureAfter cooling
- stirringthe mixture was stirred for an hour
- customthe organic layer and aqueous layer were separated
- extractionto extraction with AcOEt
- dry with materialdried with MgSO4
- filtrationfiltered
- concentrationconcentrated
- customThe residue was purified by silica gel column chromatography (n-hexane/AcOEt=3/1)
Sources & evidence
- ORD record
- ord-78c1fca938e8406d9dc551a15f332c31
- Source dataset
- uspto-grants-2003_07
- Patent number
- US06589984B1
Reaction notes
Loading…