Sodium Iodide → [4-(4-Methoxy-7-morpholin-4-yl-benzothiazol-2-ylcarbamoyl)-2-oxo-2H-pyridin-1-yl]-acetic Acid Ethyl Ester

HRID 1358927Notes

Reaction equation

HRID 1358927 reaction equation
C[O:2][C:3]1[CH:4]=[C:5]([CH:26]=[CH:27][N:28]=1)[C:6]([NH:8][C:9]1[S:10][C:11]2[C:17]([N:18]3[CH2:23][CH2:22][O:21][CH2:20][CH2:19]3)=[CH:16][CH:15]=[C:14]([O:24][CH3:25])[C:12]=2[N:13]=1)=[O:7].[I-].[Na+].Br[CH2:32][C:33]([O:35][CH2:36][CH3:37])=[O:34]>CN(C=O)C>[CH2:36]([O:35][C:33](=[O:34])[CH2:32][N:28]1[CH:27]=[CH:26][C:5]([C:6](=[O:7])[NH:8][C:9]2[S:10][C:11]3[C:17]([N:18]4[CH2:19][CH2:20][O:21][CH2:22][CH2:23]4)=[CH:16][CH:15]=[C:14]([O:24][CH3:25])[C:12]=3[N:13]=2)=[CH:4][C:3]1=[O:2])[CH3:37]

Participants

5

Reactant 3

HCID 5238Sodium IodideHCID 7748Ethyl bromoacetateHCID 101942942-Methoxy-N-(4-methoxy-7-morpholin-4-yl-benzothiazol-2-yl)-isonicotinamide

Product 1

HCID 10238755[4-(4-Methoxy-7-morpholin-4-yl-benzothiazol-2-ylcarbamoyl)-2-oxo-2H-pyridin-1-yl]-acetic Acid Ethyl Ester

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

From 2-methoxy-N-(4-methoxy-7-morpholin-4-yl-benzothiazol-2-yl)-isonicotinamide with sodium iodide and ethyl bromoacetate in DMF. ES-MS m/e (%): 495 (M+Na+, 25), 473 (M+H+, 100).

Sources & evidence

ORD record
ord-bd8f81ed8f2b4bbe8080250651fe07ce
Source dataset
uspto-grants-2003_07
Patent number
US06599901B1

Reaction notes

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