Sodium Iodide → 2-oxo-1-Pyridin-2-ylmethyl-1,2-dihydro-pyridine-4-carboxylic Acid (4-Methoxy-7-morpholin-4-yl-benzothiazol-2-yl)-amide

HRID 1358928Notes

Reaction equation

HRID 1358928 reaction equation
C[O:2][C:3]1[CH:4]=[C:5]([CH:26]=[CH:27][N:28]=1)[C:6]([NH:8][C:9]1[S:10][C:11]2[C:17]([N:18]3[CH2:23][CH2:22][O:21][CH2:20][CH2:19]3)=[CH:16][CH:15]=[C:14]([O:24][CH3:25])[C:12]=2[N:13]=1)=[O:7].[I-].[Na+].Br.BrC[CH2:34][C:35]1[CH:40]=[CH:39][CH:38]=[CH:37][N:36]=1>CN(C=O)C>[CH3:25][O:24][C:14]1[C:12]2[N:13]=[C:9]([NH:8][C:6]([C:5]3[CH:26]=[CH:27][N:28]([CH2:34][C:35]4[CH:40]=[CH:39][CH:38]=[CH:37][N:36]=4)[C:3](=[O:2])[CH:4]=3)=[O:7])[S:10][C:11]=2[C:17]([N:18]2[CH2:19][CH2:20][O:21][CH2:22][CH2:23]2)=[CH:16][CH:15]=1

Participants

5

Reactant 3

HCID 5238Sodium IodideHCID 101942942-Methoxy-N-(4-methoxy-7-morpholin-4-yl-benzothiazol-2-yl)-isonicotinamideHCID 129138592-(2-Bromoethyl)pyridine hydrobromide

Product 1

HCID 102388362-oxo-1-Pyridin-2-ylmethyl-1,2-dihydro-pyridine-4-carboxylic Acid (4-Methoxy-7-morpholin-4-yl-benzothiazol-2-yl)-amide

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

From 2-methoxy-N-(4-methoxy-7-morpholin-4-yl -benzothiazol-2-yl)-isonicotinamide with sodium iodide and 2-(bromoethyl)pyridine hydrobromide in DMF. ES-MS m/e (%): 500 (M+Na+, 30), 478 (M+H+, 100).

Sources & evidence

ORD record
ord-71e57cc6ccc8474cb7cce89f5a466e67
Source dataset
uspto-grants-2003_07
Patent number
US06599901B1

Reaction notes

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