6-Chlorothymol → HCID 59483417, compound

HRID 1359932Notes

Reaction equation

HRID 1359932 reaction equation
[Cl:1][C:2]1[C:7]([CH3:8])=[CH:6][C:5]([OH:9])=[C:4]([CH:10]([CH3:12])[CH3:11])[CH:3]=1.[P:13](Cl)([Cl:16])([Cl:15])=[O:14].CCN(CC)CC>CCOCC>[P:13]([Cl:16])([Cl:15])([O:9][C:5]1[CH:6]=[C:7]([CH3:8])[C:2]([Cl:1])=[CH:3][C:4]=1[CH:10]([CH3:12])[CH3:11])=[O:14]

Participants

5

Reactant 3

HCID 69826-ChlorothymolHCID 8471TriethylamineHCID 24813Phosphorus oxychloride

Product 1

HCID 59483417HCID 59483417, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

Following the procedure described for Example 1, Step 1, treatment of a solution (0.174 M) in Et2O of 4-chloro-2-isopropyl-5-methyl-phenol with phosphorus oxychloride (1.0 eq.) and Et3N (1.0 eq.) provided the title compound as a colorless oil. 31P NMR (300 MHz, CD3OD): δ 4.54.

Sources & evidence

ORD record
ord-2dea10abbb3145fa9230811ce971211c
Source dataset
uspto-grants-2011_02
Patent number
US07879815B2

Reaction notes

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