反应详情

温度

90 °C

To a solution of 4-bromo-2,6-difluorobenzyl methanesulfonate (from Step A above) in DMF (400 mL) was added LiBr (28.8 g, 335 mmol) and heated to 90° C. for 45 minutes. The reaction was cooled to room temperature and diluted with EtOAc. The organic layer was washed with water (5×), brine (2×) dried over MgSO4, and concentrated in vacuo to yield a brown oil. The crude residue was purified via silica gel column chromatography (CH2Cl2/hexanes) to yield the title compound (24 g).

1. temperatureThe reaction was cooled to room temperature
2. washThe organic layer was washed with water (5×), brine (2×)
3. dry with materialdried over MgSO4
4. concentrationconcentrated in vacuo
5. customto yield a brown oil
6. customThe crude residue was purified via silica gel column chromatography (CH2Cl2/hexanes)