Potassium Cation → N-{4-[6-(3-Chloro-5-methyl-benzoyl)-5-isopropyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-ylmethyl]-pyridin-2-yl}-acetamide

HRID 136132Notes

Reaction equation

HRID 136132 reaction equation
[C:46](=[O:47])([O-:48])[O-:49].[CH3:13][CH2:14][N:15]([CH2:16][CH3:17])[CH2:18][CH3:19].[CH3:20][S:21](=[O:22])(=[O:23])[Cl:24].[CH:54]([Cl:55])([Cl:56])[Cl:57].[Cl:25][c:26]1[cH:27][c:28]([C:29](=[O:30])[c:31]2[c:32]([CH:39]([CH3:40])[CH3:41])[c:33](=[O:38])[nH:34][c:35](=[O:37])[nH:36]2)[cH:42][c:43]([CH3:45])[cH:44]1.[I-:52].[K+:50].[K+:51].[Li+:53].[O:58]=[CH:59][N:60]([CH3:61])[CH3:62].[OH:1][CH2:2][c:3]1[cH:4][c:5]([NH:9][C:10]([CH3:11])=[O:12])[n:6][cH:7][cH:8]1>>[CH2:2]([c:3]1[cH:4][c:5]([NH:9][C:10]([CH3:11])=[O:12])[n:6][cH:7][cH:8]1)[n:36]1[c:31]([C:29]([c:28]2[cH:27][c:26]([Cl:25])[cH:44][c:43]([CH3:45])[cH:42]2)=[O:30])[c:32]([CH:39]([CH3:40])[CH3:41])[c:33](=[O:38])[nH:34][c:35]1=[O:37]

Participants

11

Reactant 10

HCID 813Potassium Cation2×HCID 6212ChloroformHCID 6228DimethylformamideHCID 8471TriethylamineHCID 19660Carbonate IonHCID 28486Lithium ionHCID 30165Iodide IonHCID 31297Methanesulfonyl chlorideHCID 213032376-(3-Chloro-5-methyl-benzoyl)-5-isopropyl-1H-pyrimidine-2,4-dioneHCID 23151114N-(4-(hydroxymethyl)pyridin-2-yl)acetamide

Product 1

HCID 66705490N-{4-[6-(3-Chloro-5-methyl-benzoyl)-5-isopropyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-ylmethyl]-pyridin-2-yl}-acetamide

Sources & evidence

ORD record
ord-f823932d380446b4a96a4fc326c24e23
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (9/10)

Reaction notes

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