反应详情

温度

120 °C

N,N-Dimethylacetamide (42 mL), 16.2 g of 1,2-dichloro-4-nitrobenzene, 12 g of 4-chlorobenzyl alcohol, and 8.7 g of potassium carbonate were mixed together, and the mixture was stirred with heating at 100 to 140° C. for 30 hr. This reaction solution was concentrated under the reduced pressure. The residue was dissolved in 100 mL of ethyl acetate and 100 mL of toluene, and the solution was washed with water and brine. The organic layer was concentrated under the reduced pressure, and the residue was recrystallized from ethanol to give 11.77 g of 2-chloro-1-(4-chlorobenzyloxy)-4-nitrobenzene (yield 46.9%).

1. concentrationThis reaction solution was concentrated under the reduced pressure
2. dissolutionThe residue was dissolved in 100 mL of ethyl acetate
3. wash100 mL of toluene, and the solution was washed with water and brine
4. concentrationThe organic layer was concentrated under the reduced pressure
5. customthe residue was recrystallized from ethanol