反应详情

To a THF (8 mL) solution of 3-ethoxy-4-(4-methyl-1H-imidazole-1-yl)benzaldehyde (60 mg), (indan-1-ylcarbamoylmethyl)phosphonic acid diethyl ester (81 mg) and lithium hydroxide monohydrate (22 mg) were added, and the reaction mixture was agitated at room temperature for 14 hours. Water and ethyl acetate were added to the reaction solution after the reaction ended, and the organic layer was separated. The obtained organic layer was washed with a saturated sodium chloride solution, and the solvent was evaporated under reduced pressure after dried over anhydrous magnesium sulfate. The obtained residue was purified by silica gel column chromatography (elution solvent: heptane-ethyl acetate 1:4), and 23 mg (23%) of the title compound was obtained. The physical properties of the compound are as follows.

1. customthe organic layer was separated
2. washThe obtained organic layer was washed with a saturated sodium chloride solution
3. customthe solvent was evaporated under reduced pressure
4. dry with materialafter dried over anhydrous magnesium sulfate
5. customThe obtained residue was purified by silica gel column chromatography (elution solvent: heptane-ethyl acetate 1:4)