Hydrochloric Acid → HCID 86602484, compound

HRID 1362693Notes

Reaction equation

HRID 1362693 reaction equation
C1COCC1.[Cl:6][C:7]1[N:8]([C:12]2[CH:17]=[CH:16][C:15]([CH:18]3OCC[O:19]3)=[CH:14][C:13]=2[O:23][CH3:24])[CH:9]=[CH:10][N:11]=1.Cl.[OH-].[Na+]>C(OCC)(=O)C>[Cl:6][C:7]1[N:8]([C:12]2[CH:17]=[CH:16][C:15]([CH:18]=[O:19])=[CH:14][C:13]=2[O:23][CH3:24])[CH:9]=[CH:10][N:11]=1

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 8028TetrahydrofuranHCID 14798Sodium HydroxideHCID 66961006HCID 66961006, compound

Product 1

HCID 86602484HCID 86602484, compoundYield 100%

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

To a THF (40 mL) solution of 2-chloro-1-(4-[1,3]dioxolan-2-yl-2-methoxyphenyl)-1H-imidazole (3.19 g), 5N hydrochloric acid (15 mL) was added and the reaction solution was agitated for 2 hours. The reaction mixture was made basic with 5N sodium hydroxide aqueous solution, ethyl acetate was added and the organic layer was partitioned. The organic layer obtained was washed with a saturated saline solution, dried with anhydrous magnesium sulfate and concentrated under reduced pressure to yield 2.69 g of the title compound. The physical properties of the compound are as follows.

Workup

  1. additionwas added
  2. customthe organic layer was partitioned
  3. customThe organic layer obtained
  4. washwas washed with a saturated saline solution
  5. dry with materialdried with anhydrous magnesium sulfate
  6. concentrationconcentrated under reduced pressure

Sources & evidence

ORD record
ord-6a3ce1dd52b34157b3bbd75079055678
Source dataset
uspto-grants-2011_02
Patent number
US07880009B2

Reaction notes

Loading…