Dabco → HCID 58916981, compound

HRID 1362843Notes

Reaction equation

HRID 1362843 reaction equation
[NH2:1][C:2]([CH3:22])([CH2:11][O:12][C:13]1[CH:18]=[CH:17][C:16]([O:19][CH2:20][CH3:21])=[CH:15][CH:14]=1)[C:3]([N:5]1[CH2:10][CH2:9][O:8][CH2:7][CH2:6]1)=[O:4].C1N2CCN(CC2)C1.[C:31]1([CH2:37][S:38](Cl)(=[O:40])=[O:39])[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=1>O1CCCC1>[CH2:20]([O:19][C:16]1[CH:17]=[CH:18][C:13]([O:12][CH2:11][C:2]([CH3:22])([NH:1][S:38]([CH2:37][C:31]2[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=2)(=[O:40])=[O:39])[C:3]([N:5]2[CH2:10][CH2:9][O:8][CH2:7][CH2:6]2)=[O:4])=[CH:14][CH:15]=1)[CH3:21]

Participants

5

Reactant 3

HCID 9237DabcoHCID 74740Phenylmethanesulfonyl chlorideHCID 66921564HCID 66921564, compound

Product 1

HCID 58916981HCID 58916981, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

0.370 g 2-Amino-3-(4-ethoxy-phenoxy)-2methyl-1-morpholin-4-yl-propan-1-one and 0.276 g DABCO are dissolved in 8 ml tetrahydrofurane. After addition of 0.274 phenyl-methane sulfonyl chloride the mixture is stirred for 20 h at room temperature. This mixture is then subjected to flash chromatography without further work-up to yield 260 mg of a white solid. M.p. 109-111° C.

Sources & evidence

ORD record
ord-7c91ec8d5db74b57ba320bbd42b66f0e
Source dataset
uspto-grants-2011_02
Patent number
US07884103B2

Reaction notes

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