Dabco → HCID 58916980, compound

HRID 1362844Notes

Reaction equation

HRID 1362844 reaction equation
[NH2:1][C:2]([CH3:20])([CH2:9][O:10][C:11]1[CH:16]=[CH:15][C:14]([O:17][CH2:18][CH3:19])=[CH:13][CH:12]=1)[C:3]([NH:5][CH2:6][C:7]#[CH:8])=[O:4].C1N2CCN(CC2)C1.[C:29]1([CH2:35][S:36](Cl)(=[O:38])=[O:37])[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=1>O1CCCC1>[CH2:18]([O:17][C:14]1[CH:13]=[CH:12][C:11]([O:10][CH2:9][C:2]([CH3:20])([NH:1][S:36]([CH2:35][C:29]2[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=2)(=[O:38])=[O:37])[C:3]([NH:5][CH2:6][C:7]#[CH:8])=[O:4])=[CH:16][CH:15]=1)[CH3:19]

Participants

5

Reactant 3

HCID 9237DabcoHCID 74740Phenylmethanesulfonyl chlorideHCID 860344762-Amino-3-(4-ethoxy-phenoxy)-2methyl-N-prop-2-ynyl-propionamide

Product 1

HCID 58916980HCID 58916980, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

0.880 g 2-Amino-3-(4-ethoxy-phenoxy)-2methyl-N-prop-2-ynyl-propionamide and 0.233 g DABCO are dissolved in 8 ml tetrahydrofurane. After addition of 0.232 phenyl-methansulfonyl chloride the mixture is stirred for 20 hours. This mixture is then subjected to flash chromatography without further work-up to yield 320 mg of a white solid. M.p. 155-156° C.

Sources & evidence

ORD record
ord-10e5aaa86da2418490242689dbe2de66
Source dataset
uspto-grants-2011_02
Patent number
US07884103B2

Reaction notes

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