Methyl 2-chlorobenzoate → HCID 131728666, compound

HRID 1363373Notes

Reaction equation

HRID 1363373 reaction equation
[OH:1][C:2]1[C:7]([C@@H:8]2[CH2:13][CH2:12][N:11]([CH3:14])[CH2:10][C@H:9]2[OH:15])=[C:6]([O:16][CH3:17])[CH:5]=[C:4]([O:18][CH3:19])[C:3]=1[C:20](=[O:22])[CH3:21].[Cl:23][C:24]1[CH:33]=[CH:32][CH:31]=[CH:30][C:25]=1[C:26](OC)=O.[H-].[Na+]>CN(C=O)C>[Cl:23][C:24]1[CH:33]=[CH:32][CH:31]=[CH:30][C:25]=1[C:26]1[O:1][C:2]2[C:3]([C:20](=[O:22])[CH:21]=1)=[C:4]([O:18][CH3:19])[CH:5]=[C:6]([O:16][CH3:17])[C:7]=2[C@@H:8]1[CH2:13][CH2:12][N:11]([CH3:14])[CH2:10][C@H:9]1[OH:15]

Participants

5

Reactant 3

HCID 11895Methyl 2-chlorobenzoateHCID 24758Sodium hydrideHCID 131728665HCID 131728665, compound

Product 1

HCID 131728666HCID 131728666, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

Compound of example 105 (9 g, 29 mmol) in dry DMF (50 mL) was reacted methyl 2-chlorobenzoate (16.5 g, 96.7 mmol) in the presence of NaH (50%, 6.99 g, 145.6 mmol) as described in example 16 to obtain the title compound.

Sources & evidence

ORD record
ord-3fe97e9812e74605bde387897da78036
Source dataset
uspto-grants-2011_02
Patent number
US07884127B2

Reaction notes

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