Methyl 2-chlorobenzoate → HCID 66933942, compound

HRID 1363383Notes

Reaction equation

HRID 1363383 reaction equation
[OH:1][C:2]1[C:7]([C@@H:8]2[CH2:13][CH2:12][N:11]([C:14]3[CH:19]=[CH:18][C:17]([O:20][CH3:21])=[CH:16][CH:15]=3)[CH2:10][C@H:9]2[OH:22])=[C:6]([O:23][CH3:24])[CH:5]=[C:4]([O:25][CH3:26])[C:3]=1[C:27](=[O:29])[CH3:28].[Cl:30][C:31]1[CH:40]=[CH:39][CH:38]=[CH:37][C:32]=1[C:33](OC)=O.[H-].[Na+]>CN(C=O)C>[Cl:30][C:31]1[CH:40]=[CH:39][CH:38]=[CH:37][C:32]=1[C:33]1[O:1][C:2]2[C:3]([C:27](=[O:29])[CH:28]=1)=[C:4]([O:25][CH3:26])[CH:5]=[C:6]([O:23][CH3:24])[C:7]=2[C@@H:8]1[CH2:13][CH2:12][N:11]([C:14]2[CH:15]=[CH:16][C:17]([O:20][CH3:21])=[CH:18][CH:19]=2)[CH2:10][C@H:9]1[OH:22]

Participants

5

Reactant 3

HCID 11895Methyl 2-chlorobenzoateHCID 24758Sodium hydrideHCID 131728674HCID 131728674, compound

Product 1

HCID 66933942HCID 66933942, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

Compound of example 121 (2.0 g, 5.0 mmol) in dry DMF (25 mL) was reacted with methyl 2-chlorobenzoate (2.55 g, 15 mmol) in the presence of NaH (50%, 1.19 g, 25 mmol) as described in example 16 to obtain the title compound.

Sources & evidence

ORD record
ord-5e47ac0b92cc4072959721321a4df0dd
Source dataset
uspto-grants-2011_02
Patent number
US07884127B2

Reaction notes

Loading…