Trifluoroacetic acid → HCID 59840103, compound

HRID 1365927Notes

Reaction equation

HRID 1365927 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][N:11]([C:14]([N:16]2[CH2:20][C@@H:19]([C:21]3[CH:26]=[CH:25][C:24]([F:27])=[CH:23][CH:22]=3)[C@H:18]([N:28]([C:30](=[O:48])[C:31]([C:34]3[CH:39]=[C:38]([C:40]([F:43])([F:42])[F:41])[CH:37]=[C:36]([C:44]([F:47])([F:46])[F:45])[CH:35]=3)([CH3:33])[CH3:32])[CH3:29])[CH2:17]2)=[O:15])[CH2:10][CH2:9]1)=O)(C)(C)C.C(O)(C(F)(F)F)=O.C([O-])(O)=O.[Na+]>C(Cl)Cl>[F:47][C:44]([F:45])([F:46])[C:36]1[CH:35]=[C:34]([C:31]([CH3:32])([CH3:33])[C:30]([N:28]([C@H:18]2[C@H:19]([C:21]3[CH:26]=[CH:25][C:24]([F:27])=[CH:23][CH:22]=3)[CH2:20][N:16]([C:14]([N:11]3[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]3)=[O:15])[CH2:17]2)[CH3:29])=[O:48])[CH:39]=[C:38]([C:40]([F:42])([F:41])[F:43])[CH:37]=1

Participants

5

Reactant 3

HCID 6422Trifluoroacetic acidHCID 516892Sodium BicarbonateHCID 59840109HCID 59840109, compound

Product 1

HCID 59840103HCID 59840103, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a stirred solution of rac-4-[(3S,4R)-3-{[2-(3,5-Bis-trifluoromethyl-phenyl)-2-methyl-propionyl]-methyl-amino}-4-(4-fluoro-phenyl)-pyrrolidine-1-carbonyl]-piperazine-1-carboxylic acid tert-butyl ester (21 mg, 0.30 mmol) in CH2Cl2 (4 ml) at RT, was added TFA (1 ml). After 1 hour, the reaction mixture was neutralized by addition of an aqueous solution of NaHCO3. The organic phases were dried over Na2SO4 to yield the title compound as a white solid.

Workup

  1. dry with materialThe organic phases were dried over Na2SO4

Sources & evidence

ORD record
ord-95d4aa14c46c4af695ad91968962a5d1
Source dataset
uspto-grants-2011_02
Patent number
US07893062B2

Reaction notes

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