反应详情

10-Bromodecan-1-ol (4.6 g) was dissolved in 20 ml of dried THF, and sodium hydride (933.6 mg) was added to this solution. The reaction mixture was stirred at room temperature for 30 minutes, then benzyl bromide (2.78 ml) was added using a syringe, and the reaction mixture was refluxed for 24 hours while stirring. Saturated ammonium chloride solution was added to the reaction mixture, which was then extracted with diethyl ether. The organic layer was washed with saline solution, dried over magnesium sulfate, and filtered, and the solvent was distilled off under reduced pressure. Purification of the residue by silica gel flash chromatography (hexane:dichloromethane=8:2) gave 1-((10-bromodecanoxy)methyl)benzene as a colorless oil at an 88% yield.

1. temperaturethe reaction mixture was refluxed for 24 hours
2. stirringwhile stirring
3. extractionwas then extracted with diethyl ether
4. washThe organic layer was washed with saline solution
5. dry with materialdried over magnesium sulfate
6. filtrationfiltered
7. distillationthe solvent was distilled off under reduced pressure
8. customPurification of the residue by silica gel flash chromatography (hexane:dichloromethane=8:2)