反应详情

Chloroacetaldehyde diethyl acetal (2.00 g), potassium benzoate (1.91 g), potassium bromide (0.30 g) and DMF (20 mL) were placed in a three-neck flask, followed by refluxing. Twenty hours later, the reaction mixture was cooled to room temperature, and water (30 mL) and ethyl acetate (80 mL) were added thereto, followed by stirring. After filtration, the organic layer was washed with water (30 mL) and was dried over anhydrous sodium sulfate. Subsequent filtration and vacuum concentration yielded the target compound (0.97 g) in a yield of 31%.

1. temperatureby refluxing
2. filtrationAfter filtration
3. washthe organic layer was washed with water (30 mL)
4. dry with materialwas dried over anhydrous sodium sulfate
5. filtrationSubsequent filtration and vacuum concentration