Tetrahydrofuran → 7'-fluorospiro[furo[2,3-f][1,3]benzodioxole-7,3'-indol]-2'(1'H)-one

HRID 136841Notes

Reaction equation

HRID 136841 reaction equation
[CH2:22]([P:23]([CH2:24][CH2:25][CH2:26][CH3:27])[CH2:28][CH2:29][CH2:30][CH3:31])[CH2:32][CH2:33][CH3:34].[CH2:51]1[O:52][CH2:53][CH2:54][CH2:55]1.[F:1][c:2]1[cH:3][cH:4][cH:5][c:6]2[c:10]1[NH:9][C:8](=[O:11])[CH:7]2[c:12]1[cH:13][c:14]2[c:15]([cH:19][c:20]1[OH:21])[O:16][CH2:17][O:18]2.[N:35]([C:36]([O:37][C:38]([CH3:39])([CH3:40])[CH3:41])=[O:42])=[N:43][C:44]([O:45][C:46]([CH3:47])([CH3:48])[CH3:49])=[O:50]>>[F:1][c:2]1[cH:3][cH:4][cH:5][c:6]2[c:10]1[NH:9][C:8](=[O:11])[C:7]21[c:12]2[cH:13][c:14]3[c:15]([cH:19][c:20]2[O:21][CH2:22]1)[O:16][CH2:17][O:18]3

Participants

5

Reactant 4

HCID 8028TetrahydrofuranHCID 13831TributylphosphineHCID 97268Di-tert-butyl azodicarboxylateHCID 588725467-fluoro-3-(6-hydroxy-1,3-benzodioxol-5-yl)-1,3-dihydro-2H-indol-2-one

Product 1

HCID 592633687'-fluorospiro[furo[2,3-f][1,3]benzodioxole-7,3'-indol]-2'(1'H)-one

Sources & evidence

ORD record
ord-3a692bc5e76a4e468e0438bdcd80ae13
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (9/10)

Reaction notes

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