反应详情

A mixture composed of 12 g of guanidine hydrochloride, 9 g of sodium ethoxide and 100 ml of ethanol was heated under reflux for 1 hour, and then the reaction solution was cooled to room temperature, further mixed with 10 g of dimethyl methoxymalonate and heated under reflux for 48 hours. The reaction solution was cooled to room temperature, adjusted to a pH value of about 4 by adding 1 N hydrochloric acid solution and stirred, and then the thus precipitated powder was collected by filtration to obtain 2.0 g of the title compound.

1. temperaturewas heated
2. temperatureunder reflux for 1 hour
3. temperatureheated
4. temperatureunder reflux for 48 hours
5. temperatureThe reaction solution was cooled to room temperature
6. filtrationthe thus precipitated powder was collected by filtration